Peptidi di difesa dell'ospite - evoluzione e relazioni struttura-attività (Prof. Tossi)

Prof. Alessandro Tossi

Tel: +39 0405588705
email:  atossi
Skype:  alessandro.tossi



Prof. Alessandro Tossi obtained his PhD degree at Trinity College, the University of Dublin, in 1987, with a thesis on the study of the binding and photochemical reactions of ruthenium polypyridyl complexes with oligonucleotides. Subsequently, he carried out post-doctoral research on the photochemistry and radiochemistry of nucleic acids at the Max-Planck-Institute für Strahlenchemie in Mülheim a.d. Ruhr, Germany and at the Chemistry Dept. in Dublin University, where he studied site-specific photochemical modifications of DNA. He then studied DNA/peptide interactions as a Training Fellow at the International Centre for Genetic Engineering and Biotechnology (ICGEB) in Trieste, where he learnt peptide synthesis, bioinformatics and molecular modelling techniques. In 1992 he became Assistant Professor, and in 2002 Associate Professor, in the Faculty of Pharmaceutical Sciences of the University of Trieste. He has contributed to the identification and characterization of several mammalian antimicrobial peptides of the cathelicidin family, and designed and synthesized numerous artificial antimicrobial peptides for studies on SAR, mode of action and effects of evolutionary variations. He is interested in the evolution of host-defence peptides in mammals, including cathelicidins, beta-defensins, histatins and hepcidins. He has also contributed to the design and synthesis of numerous peptidomimetic inhibitors of HIV aspartic protease.  He is co-inventor in patents on both AMPs and HIV inhibitors.

He has been involved in several research projects financed by the Italian CNR, Ministry of Research, National Institute of Health and FVG Region. He was unit coordinator in 5th and 7th Framework EU projects on AMPs.  He coordinated the FVG regional project R3A2 (Regional Research Network on Anti-infective Agents). He has actively collaborated with research groups in both industry and academia, in Italy, Germany, Denmark, Norway, Finland, Croatia and Israel.  He is co-author of more than 90 papers in international refereed journals (Top Italian Scientists rank level 94; Google Scholar)



Ultimo aggiornamento: 19-01-2018 - 21:30