Il giorno 04 Giugno p.v. alle 15:00 - presso l'Aula  1B - Edificio H3 -  Comprensorio Principale dell'Università degli Studi di Trieste -  il prof. Agenor Ruiz LIMON terrà un seminario dal titolo "Mechanisms of synaptic resilience to Alzheimer's disease Neuropathology".

 "Mechanisms of synaptic resilience to Alzheimer's disease Neuropathology"

Abstract:

There is ample scientific evidence that toxic oligomers of Abeta and Tau, considered the major neuropathological factors in Alzheimer’s disease (AD) lead to synaptic failure and dementia. However, some individuals can accumulate significant AD neuropathology without clinical manifestations. The existence of non-demented with high neuropathology (NDAN) individuals indicates that cognitive resilience to AD neuropathology is possible, but the functional status of their synapses, a major target of toxic oligomers, is unknown.  In this talk , we will discuss the relationships between gene and protein expression with the function of synapses in these individuals. Our results suggest a tug-of-war between active pathological processes and compensatory enhancement of synaptic pathways in NDAN individuals. These results provide converging evidence of functional remodeling of synapses in resilient subjects. 

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