Chromatin and epigenetics in cancer (Prof. Manfioletti)

Prof. Guidalberto Manfioletti

Tel: +39 040 558 8720/8719/8722 (lab)



Guidalberto Manfioletti is Associate Professor in Biochemistry at the University of Trieste since 2001.

Professor Manfioletti has a B.S. degree in Biology from the University of Trieste. He had his research training at EMBL in Heidelberg (Germany) and at ICGEB in Trieste as a fellow and at the University of Trieste as Assistant professor. Among his research experiences, he has been visiting scientist at the Biophysics Laboratories, University of Portsmouth (Portsmouth), the Institute for Cancer Research, Chester Beatty Laboratories (London), and the Schepens Institute, Harvard Medical School (Boston).

His research interest focuses mainly in the molecular oncology field. Particularly, on the oncogenic role of the chromatin architectural transcription factor High Mobility Group A (HMGA) proteins.

Among his main contribution:

- the cloning and characterization of HMGA2 (Nucleic Acids Res. 1991)
- the characterization of HMGA2 as an architectural transcription factor (Nucl. Acids. Res. 1998).
- the cloning and characterization of the mouse Hmga2 gene (BBRC, 1999).
- the discovery of a HMGA2-dependent regulation of cyclin A (Mol. Cell. Biol. 2003).
- the discovery of the inhibitory role of HMGA1 towards p53 family members (Cancer Res. 2006).
- the characterization of a molecular HMGA network. (BBA 2010)
- the characterization of the oncogenic role of HMGA1 in promoting metastatic processes in basal-like breast cancer cells (Oncotarget 2013)

Professor Manfioletti has more than 80 papers published in international scientific journals and is reviewer for several scientific journals.



Last update: 08-23-2019 - 21:30