Molecular liver pathophysiology (Dr. Sorrentino)


Dr. Giovanni Sorrentino

SSD BIO/13, Applied Biology


Phone: (+ 39) 040 558 8644

Twitter: @sorrentinolab


Building RRA, room 131
Department of Life Sciences (DSV)
University of Trieste
via Valerio 28-28/1 - 34127 Trieste, Italy


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Dr. Giovanni Sorrentino studied Medical and Pharmaceutical Biotechnology at the University of Ferrara (Italy). In 2014 he obtained his PhD in Molecular Biomedicine at the University of Trieste (Italy), working under the supervision of Prof. Giannino Del Sal. From 2014 to 2017, he did his first postdoctoral training funded by a FIRC fellowship at the National Laboratory CIB, Area Science Park, Trieste. In 2017, he received a FEBS (Federation of European Biochemical Societies) long-term postdoctoral fellowship to join the Laboratory of Metabolic Signaling at the Institute of Bioengineering, École Polytechnique Fédérale de Lausanne (Switzerland) led by Prof. Kristina Schoonjans. In 2020, thanks to a generous support from AIRC and Telethon, he returned to Italy to lead an independent research group at the Department of Life Science, University of Trieste.
His initial scientific studies have mainly focused on understanding how cancer cells perceive mechanical signals from their microenvironment and how this perception integrates with cellular metabolism to promote cancer stem cell traits. In this context, his major contribution has been involved in the identification of the mevalonate pathway as a crucial metabolic input for mechano-transducers YAP/TAZ and the oncogene mutant-p53 in cancer stem cells. These works were published in two papers in Nature Cell Biology: Sorrentino G. et al. 2014 and Ingallina E.*, Sorrentino G.* et al. 2018. Moreover, on the basis of this work, he received an Italian scientific award for young investigators (Chiara D’onofrio Junior Award) from the Italian Society of Biophysics and Molecular Biology (SIBBM).
More recently, his research lines focused on understanding the fundamental principles that regulate intestinal and liver stem cell renewal/regeneration and at studying how metabolic pathways and the physical microenvironment integrate each other to control stemness. In this context, he pioneered the bioengineering techniques for the derivation of hepatic organoids in fully synthetic matrices and the methodologies to investigate the role of ECM stiffness on liver disease traits (Sorrentino et al. 2020, Nature Communications).



Last update: 05-07-2021 - 21:30