Phagocyte physiopathology (Dr. Menegazzi)

Dr. Renzo Menegazzi

Phone:  +39 040 558 8648
Fax:  +39 040 558 4023
Email:  menegazz@units.it

 

Biosketch

Renzo Menegazzi is established researcher in General Pathology at the University of Trieste since 1992.

Dr. Menegazzi has a B.S. degree in Biology from the University of Trieste and a PhD degree in Experimental Pathology. In 1989 he has been appointed to the Faculty of Medicine of the University of Trieste as assistant professor of General Pathology. Since 1989 dr. Menegazzi has been teaching at single-cycle and first-cycle degree courses at the Faculty of Medicine (now Department of Medicine, Surgery and Health Sciences). Starting from 2013, he also teaches General Pathology at the first-cycle degree course of Biological Sciences and Technologies and, from 2016, he teaches Molecular Pathology at the master degree of Medical Biotechnologies, at the Department of Life Sciences.

In 1983 he visited the Department of Blood Cell Chemistry at the Central Laboratory of The Netherlands Red Cross Blood Transfusion Service of Amsterdam and the Department of Biochemistry of the University of Amsterdam, where he acquired basic techinques for the isolation of neutrophils and eosinophils from human blood and the purification of myeloperoxidase and eosinophil peroxidase from human leukocyte crude extracts. In 1992, he visited the Institute of General Pathology of the University of Verona, to perform studies on the intracellular signaling pathways triggered in neutrophils by inflammatory cytokines, chemotactic factors and cross-linking of adhesive molecules. 

His research interest focuses on innate immunity, particularly the pathophysiology of human granulocytes (neutrophils, eosinophils). In this field, his work has contributed to elucidate some molecular mechanisms underlying:

(a) the interaction between human granulocyte-derived peroxidases (i.e. neutrophil myeloperoxidase and eosinophil peroxidase) and inflammatory cells; (b) the activation of neutrophils by Tumor Necrosis Factor;

(c) the adhesion of eosinophils to human vascular endothelial cells.

Among his main contribution to the above topics:

  • a detailed EM-based analysis of MPO and EPO uptake by inflammatory cells  (Am J Pathol 1986; J Pathol 1991);
  • the characterization of the role of TNF receptors and beta-2 integrins in the activation of neutrophils in contact with biologic surfaces (Blood 1994);
  • the discovery of the crucial role of chloride movements in the regulation of neutrophil functional responses (J Cell Biol 1996; J Immunol 1999; J Immunol 2000; J Immunol 2007);
  • the characterization of the pro-adhesive molecules involved in the interaction between eosinophils and endothelial cells (J Clin Invest 1991).

 

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Last update: 06-21-2021 - 21:30