Peptidi di difesa dell'ospite - meccanismo d'azione e applicazioni (Prof. Gennaro)

Prof. Renato Gennaro

Tel: +39 0405588701
Email:rgennaro @units.it

 

Biosketch

Renato Gennaro is full professor of Biochemistry since 1990. He is a member of the Department of Life Sciences at the University of Trieste.

He has a B.S. degree in Biology from the University of Trieste (1976). Research training at the Institute of Biochemistry in Trieste. Among his research experiences, he was a research fellow at the Wander-Sandoz Research Institute in Bern and at the Dept. of Organic Chemistry of the Weizmann Institute of Sciences.

His research interests have always been focused to host-defence mechanisms, in the following research fields: i) biochemistry and physiology of phagocytes, with emphasis to the mechanisms of cellular activation and of innate immune defence; ii) identification of novel antimicrobial peptides from leukocytes, characterization of their structure and biological activity; iii) chemical synthesis of fragments and analogues of antimicrobial peptides for structure/activity relationship studies; iv) in vitro and in vivo activity of natural and synthetic antimicrobial peptides against drug-resistant clinical isolates of bacteria and fungi; v) identification of new bacterial molecular targets for the development of innovative antibiotics; vi) investigation of the mode of action of Pro-rich and alpha-helical peptides via selection of resistant mutants obtained by chemical mutagenesis or transposon insertion; vii) chemical aspects of peptide synthesis; viii) nanotechnological drug-delivery systems.

Major achievements of these studies have been: i) the discovery and characterization of the cathelicidin family of antimicrobial peptides, which is the most important in mammalian host defence, together with defensins; ii) the role of Ca2+and protein kinase C-dependent phosphorylation in the activation of the NADPH oxidase and of secretion in neutrophils; iii) more recently, the possible mechanism of penetration of proline-rich antimicrobial peptides into Gram-negative bacteria by means of a plasma membrane uptake system belonging to the ABC superfamily of proteins.

Prof. Gennaro is co-author of more than 90 papers, mostly in international refereed journals, including 4 patents.

He has been invited speaker in numerous national and international Workshops, Congresses and Symposia on innate immunity and peptide biology and technology, and invited to deliver seminars in Italian and foreign Universities.

Referee for numerous international journals and for grant applications of national and international agencies.

 

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Ultimo aggiornamento: 23-01-2018 - 21:30