Non-coding RNA and genomic stability (Prof. Schoeftner)

Prof. Stefan Schoeftner

 

Tel. ++39 040 3756805
Fax. ++39 040 398990

Email: sschoeftner@units.it
Email: stefan.schoeftner@lncib.it

 

Biosketch

Stefan Schoeftner is Associate Professor in Molecular Biology at the the University of Trieste, Department of Life Sciences and Principle Investigator of the Genomic Stability Group at the Consorzio Interuniversitario per le Biotecnologie – Laboratorio Nazionale (LNCIB, Trieste). Stefan Schoeftner studied Biology/Genetics at the University of Vienna (Austria) and obtained the PhD from the same University, working at the Institute of Molecular Pathology in Vienna.
He performed his post-doctoral research at the Spanish National Cancer Center (CNIO) in Madrid and at the LNCIB in Italy. He opened his independent research group at the Italian National Cancer Research Institute, Regina Elena in Rome (Italy) in 2011. In 2013 Stefan Schoeftner transferred his research group to LNCIB in Trieste. Since 2015 he has been holding the position of Associate Professor of Molecular Biology at the University of Trieste, Department of Life Sciences.

The research interest of Stefan Schoeftner has been focused on understanding key processes that impact on the stability and structure of telomeres and the cancer genome as well as the development of novel, cell based tools for cancer research.
During his career Stefan Schoeftner discovered mechanisms that coordinate the inactivation of chromatin structures of an entire chromosome, a process called X inactivation (Schoeftner et al. EMBO Journal, 2006). He investigated the mechanism that links chromatin structure to the mechanisms that ensure the stability of DNA sequences, named telomeres, that protect the ends of chromosomes (Schoeftner et al. PNAS 2009). Further, he discovered RNA molecules derived from transcription of telomeres and having an impact on protecting the their function (Schoeftner and Blasco, Nat Cell Biol, 2008). Later on, his team identified a role for small RNAs, so called miRNAs, in controlling telomere and genomic stability in human breast cancer cells (Dinami et al. Cancer Res 2014, Dinami et al. 2017). More recently, collaborative efforts with Roberta Benetti (University of Udine, Italy) unraveled a mechanism that controls the identity and genomic stability of stem cells and cancer cells (Scarola et al. Nat Comm 2015; Commiso et al. Oncotarget 2017). To date he has authored 19 peer-reviewed scientific publications including research articles and reviews. In addition, Stefan Schoeftner is holding a patent on the use of telomeric transcripts as diagnostic and therapeutic agent (PCT/EP2008/010661).
 

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Last update: 04-03-2020 - 21:30